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  • Generic Name: (treprostinil)
    Other Brands: N/A
  • Last Revised: 01/2015
    • What is this medication and its most common uses?

      Remodulin is a medicine used to improve exercise ability in people with pulmonary arterial hypertension (PAH) (high blood pressure in the arteries of your lungs). Remodulin is administered through a very thin tube called a catheter, that is inserted just below the skin or surgically placed into your upper chest area.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Remodulin helps open up blood vessels in the lungs allowing blood to flow more easily.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Remodulin has been shown to improve exercise-related PAH symptoms, including shortness of breath.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider’s directions.

      How do I know it is working?

      You may notice an improvement in your symptoms once you begin using Remodulin. This is a good indicator that your medication is working. Your healthcare provider may ask you questions from time to time to assess how well your PAH is controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: infusion-site pain and reaction, headache, diarrhea, nausea, jaw pain, dizziness, swelling, itching, low blood pressure.

      Less common side effects may include:

      Risk of infection in the bloodstream. To reduce your risk, follow your healthcare provider’s instructions on how to properly care for your catheter and infusion pump.

    • Who should not take this medication?

      Your healthcare provider will not administer Remodulin to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Remodulin. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your weight, and may adjust your dose as needed, until the desired effect is achieved.

      If you have liver impairment, your healthcare provider may adjust your dose appropriately.

      Do not, on your own, suddenly lower your dose of Remodulin or stop using it. Sudden and dramatic changes in dose may worsen your PAH symptoms.

    • How should I take this medication?

      Use Remodulin exactly as prescribed by your healthcare provider. Do not change your dose or stop using Remodulin without first talking to your healthcare provider.

      Your catheter is attached to a small, portable pump that holds your medicine. Your pump should be on and you must carry or wear the pump at all times.

      When you receive Remodulin for the first time, you must be in a hospital or clinic where you can be monitored for any serious side effects or in case of emergency.

      Vials of Remodulin must be mixed only with Sterile Water for Injection, 0.9% Sodium Chloride Injection, Sterile Diluent for Flolan, or Sterile Diluent for Epoprostenol Sodium.

      Your healthcare provider will work closely with you and give you specific directions for preparing, storing, and using your medicine.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not mix Remodulin with any other solutions or medications before or during administration.

    • What are the possible food and drug interactions associated with this medication?

      If Remodulin is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Remodulin with the following: blood pressure medications, blood thinners (such as heparin), or water pills (such as hydrochlorothiazide).

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Remodulin during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Remodulin should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store unopened vials of Remodulin at room temperature.

      Ask your pharmacist or healthcare provider how to properly store Remodulin after it has been mixed.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.