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  • Generic Name: (hydrocodone bitartrate/ibuprofen)
    Other Brands:
  • Last Revised: 12/2014
    • What is this medication and its most common uses?

      Reprexain is a medicine used to treat short-term pain. Reprexain contains two medicines that work in two different ways to relieve your pain: hydrocodone and ibuprofen.

      Reprexain is a federally controlled substance because it has abuse potential.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Hydrocodone works in your central nervous system (the brain and spinal cord) and affects the way your body responds to pain. Ibuprofen blocks a substance in your body that is involved in causing pain and inflammation. This medicine is not used to treat pain associated with osteoarthritis (a type of arthritis that involves the breakdown of cartilage in the joints) or rheumatoid arthritis (a type of arthritis that involves inflammation of the joints).

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Reprexain has been shown to help relieve pain.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Reprexain exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel an improvement in your pain. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions from time to time to assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: headache, constipation, drowsiness, nausea, dizziness, upset stomach.

      Less common side effects may include:

      Increased chance of a life-threatening heart attack or stroke, with symptoms such as chest pain, shortness of breath, weakness, or slurring of speech.

      Reprexain has abuse potential. If you have concerns, talk to your healthcare provider for more information about abuse and addiction. Do not share Reprexain with others and take steps to protect Reprexain from theft or misuse.

      Serious breathing problems with symptoms such as slowed or shallow breathing (little chest movement with breathing); feeling faint, dizzy, or confused; or other unusual symptoms.

      Reprexain can cause ulcers and bleeding in your stomach and intestines at any time during treatment. Ulcers and bleeding can be life-threatening and may happen without warning symptoms. The chance of a person getting an ulcer or bleeding increases with longer use, smoking, drinking alcohol, older age, having poor health, and if you are taking medicines called corticosteroids (such as prednisone) or blood thinners (such as warfarin). Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or you vomit blood while taking Reprexain.

      Serious allergic reactions with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.

      Liver problems with symptoms such as nausea, fatigue, weakness, itching, yellowing of your skin or the whites of your eyes, right upper abdominal (stomach area) pain, or flu-like symptoms.

      Reprexain may cause high blood pressure (or worsen existing high blood pressure), anemia (low red blood cell counts), aseptic meningitis (brain or spinal cord inflammation), kidney problems, eye problems (such as blurred vision), or unexplained weight gain or swelling.

    • Who should not take this medication?

      Do not take Reprexain if you are allergic to it or any of its ingredients.

      Do not take Reprexain if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other nonsteroidal anti-inflammatory drug (NSAID) (such as meloxicam or naproxen).

      Do not take Reprexain for pain right before or after a heart bypass surgery.

      Do not take Reprexain during the late stages of your pregnancy.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Reprexain. Also, talk to your healthcare provider about your complete medical history, especially if you have a head injury; asthma; high blood pressure or heart failure; kidney, liver, or thyroid problems; adrenal gland problems (such as Addison's disease); problems breathing or lung disease; problems urinating or enlarged prostate; a history of ulcers or bleeding in your stomach or intestines; a history of drug or alcohol addiction, or a family history of these problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and Adolescents ≥16 years: The recommended dose is one tablet every 4-6 hours as needed for pain. Do not take more than 5 tablets in one day.

      Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.

    • How should I take this medication?

      Take Reprexain exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

    • What should I avoid while taking this medication?

      Do not drink alcohol or take prescription or over-the-counter medicines that contain alcohol while you are taking Reprexain.

      Do not drive a car, operate machinery, or engage in other dangerous activities until you know how Reprexain affects you.

    • What are the possible food and drug interactions associated with this medication?

      If Reprexain is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Reprexain with the following: alcohol, anticholinergic agents (such as ipratropium or oxybutynin), antidepressant medications known as monoamine oxidase inhibitors (MAOIs) (such as phenelzine or tranylcypromine), aspirin, blood pressure/ heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril or enalapril), certain pain medicines (such as buprenorphine, butorphanol, nalbuphine, or pentazocine), lithium, methotrexate, muscle relaxants (such as cyclobenzaprine or carisoprodol), other medicines that may make you sleepy (such as alprazolam, cetirizine, olanzapine, or morphine), warfarin, or water pills (such as furosemide or hydrochlorothiazide).

    • May I receive this medication if I am pregnant or breastfeeding?

      Do not take Reprexain if you are in the late stage of your pregnancy. The effects of Reprexain during early pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Reprexain. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Reprexain should only be taken as needed for pain.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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