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  • Generic Name: (delavirdine mesylate)
    Other Brands: N/A
  • Last Revised: 11/2015
    • What is this medication and its most common uses?

      Rescriptor is a medicine used with other anti-HIV medicines to treat HIV-1 infection.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Rescriptor works by blocking a chemical in your body that is needed for HIV-1 to multiply, thereby lowering the amount of HIV-1 in your blood.

      Rescriptor does not cure HIV-1 infection or AIDS, and you may continue to experience illnesses associated with HIV-1 infection. See your healthcare provider regularly.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Lowering the amount of HIV-1 in your blood may lower the chance of death or infection that happens when your immune system is weak.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Rescriptor exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: rash, headache, nausea, diarrhea, tiredness.

      Less common side effects may include:

      Changes in your immune system, which gets stronger and begins to fight infections that have been hidden in your body for a long time, leading to new symptoms after starting HIV treatment.

      Changes in body fat, including increased amount of fat in the upper back and neck ("buffalo hump"), in the breasts, and around the trunk.

      Serious skin rash with symptoms such as fever, blisters, mouth sores, swelling, or muscle or joint aches.

    • Who should not take this medication?

      Do not take Rescriptor if you are allergic to it or any of its ingredients.

      Do not take Rescriptor if you take medicines called alprazolam, astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine, or triazolam.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Rescriptor. Also, talk to your healthcare provider about your complete medical history, especially if you have skin problems, liver or kidney problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and adolescents ≥16 years: The recommended dose is 400 milligrams (mg) (two 200 mg-tablets or four 100-mg tablets) 3 times a day.

    • How should I take this medication?

      Take Rescriptor exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Rescriptor without first talking to your healthcare provider.

      Take Rescriptor with or without food.

      If you have trouble swallowing tablets, you may dissolve the 100-mg Rescriptor tablets in 3 ounces of water. Let the tablets sit in the water for a few minutes, then stir the water until the tablets have dissolved, and drink it right away.

      Swallow the 200-mg tablets whole.

      If you take antacids, take them at least 1 hour apart from your dose of Rescriptor.

      When your medicine starts to run low, get more from your healthcare provider or pharmacy. Do not run out of Rescriptor. The virus in your blood may increase and the virus may become harder to treat.

    • What should I avoid while taking this medication?

      Do not do anything that can spread HIV-1 to others, such as sharing needles or other injection equipment, sharing personal items that can have blood or body fluids on them (such as toothbrushes or razor blades), or having any kind of unprotected sex.

    • What are the possible food and drug interactions associated with this medication?

      If Rescriptor is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Rescriptor may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Rescriptor during pregnancy and breastfeeding are unknown. Mothers with HIV-1 should not breastfeed because HIV-1 can be passed to the baby in the breast milk. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

      If you become pregnant while taking Rescriptor, talk to your healthcare provider about registering with the Antiretroviral Pregnancy Registry. The purpose of this registry is to collect information about the safety of this medicine during pregnancy.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Rescriptor, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from heat and moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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