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  • Generic Name: (granisetron)
    Other Brands: N/A
  • Last Revised: 11/2015
    • What is this medication and its most common uses?

      Sancuso is a medicine used to prevent nausea and vomiting in people receiving certain chemotherapy treatment. Sancuso is available as a patch to be applied on the skin.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Sancuso works by blocking cells in the body from sending messages to the brain that trigger nausea and vomiting associated with chemotherapy.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Sancuso has been shown to prevent nausea and vomiting associated with chemotherapy.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Sancuso exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may notice you are experiencing less nausea and vomiting after you start using Sancuso. This is a good indicator that your medicine is working. Your healthcare provider may also ask you questions from time to time to assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: constipation.

      Less common side effects may include:

      Skin reactions, with symptoms such as redness, rashes, bumps, blisters or itching at the patch application site.

      Using Sancuso may make it harder to identify certain stomach and intestinal problems that are from other causes. Symptoms of stomach and intestinal problems may include abdominal (stomach area) pain or swelling.

      Serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells) may occur if you are also taking certain medicines to treat depression or migraines. Symptoms of serotonin syndrome include changes in mental state (such as agitation or hallucinations); a fast heartbeat; high or low blood pressure; coordination problems or muscle twitching; muscle stiffness; dizziness; flushing; tremor; seizures; or nausea, vomiting, or diarrhea.

    • Who should not take this medication?

      Do not use Sancuso if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Sancuso. Also, talk to your healthcare provider about your complete medical history, especially if you have allergies to adhesive tape, dressings, or other skin patches; pain or swelling in your abdomen; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Apply one patch to your upper outer arm, at least 1 day (24 hours) before your scheduled chemotherapy treatment. You may apply Sancuso up to 2 days (48 hours) before your scheduled chemotherapy. 

      Remove the patch at least 1 day (24 hours) after your chemotherapy is finished. Sancuso may be worn for up to 7 days, depending on how long your chemotherapy treatment lasts.

    • How should I take this medication?

      Use Sancuso exactly as prescribed by your healthcare provider.

      Apply Sancuso to a clean, dry, healthy area of skin on the outside part of your upper arm. The area you choose should not be oily, recently shaved, or have any problems (such as being cut, scraped, or irritated).

      The Sancuso patch comes inside a pouch. Do not remove the patch from the pouch until you are ready to use it. 

      Do not cut the Sancuso patch into pieces.

      Please review the instructions that came with your prescription on how to properly use the Sancuso patch.

    • What should I avoid while taking this medication?

      Do not apply any heat source (such as a heating pad or heat lamp) over or near the Sancuso patch. You should also avoid extended exposure to heat as it may increase you blood levels during the time of heat exposure.

      Do not expose your skin to direct sunlight or light from sunlamps (such as tanning beds). While you wear the patch, keep it covered with clothing if you will be in sunlight or near a sunlamp. Also, keep the skin where Sancuso was applied covered for another 10 days after the patch is taken off to protect from exposure to direct sunlight.

    • What are the possible food and drug interactions associated with this medication?

      If Sancuso is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Sancuso with the following: certain antidepressants (such as fluoxetine, venlafaxine, mirtazapine, or phenelzine), fentanyl, lithium, methylene blue, and tramadol.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Sancuso during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Sancuso should be used under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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