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  • Generic Name: (selegiline hydrochloride)
    Other Brands: N/A
  • Last Revised: 04/2014
    • What is this medication and its most common uses?

      Selegiline tablets are known as monoamine oxidase inhibitors (MAOI). Selegiline tablets are used in combination with levodopa and carbidopa to treat signs and symptoms of Parkinson's disease.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Selegiline tablets are thought to work by increasing the activity of a chemical in your brain called dopamine. By increasing dopamine activity, selegiline tablets may help improve symptoms of Parkinson's disease.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Selegiline tablets may help relieve symptoms associated with Parkinson's disease.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take selegiline tablets exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: nausea, dizziness, lightheadedness, fainting, abdominal (stomach area) pain, confusion, hallucinations, dry mouth.

      Less common side effects may include:

      If you are also taking levodopa, selegiline tablets may make some side effects of levodopa worse, such as causing uncontrolled sudden movements or make such movement you already have worse.

      Selegiline tablets may interact with certain foods (such as aged cheese and meats), causing a life-threatening increase in blood pressure with symptoms such as severe headaches. It is important that you follow any dietary recommendations your healthcare provider gives you.

      Urges to behave in a way unusual for you, such as unusual urges to gamble or increased sexual urges and behaviors.

    • Who should not take this medication?

      Do not take selegiline tablets if you are allergic to them or any of their ingredients.

      Do not take selegiline tablets if you are taking a medicine called meperidine.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with selegiline tablets. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems; history of skin cancer or mental disorder; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 5 milligrams twice a day.

    • How should I take this medication?

      Take selegiline tablets exactly as prescribed by your healthcare provider. Do not change your dose or stop taking selegiline tablets without first talking to your healthcare provider.

      Take selegiline tablets with breakfast and lunch.

    • What should I avoid while taking this medication?

      Do not take certain medications for depression (such as amitriptyline, fluoxetine, paroxetine, protriptyline, or sertraline) while you are taking selegiline tablets or within 14 days of stopping selegiline tablets. Taking these medications together with selegiline tablets can cause serious side effects.

      Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how selegiline tablets affect you.

    • What are the possible food and drug interactions associated with this medication?

      If selegiline tablets are taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining selegiline tablets with the following: certain antidepressants (such as amitriptyline, fluoxetine, paroxetine, protriptyline, or sertraline), ephedrine, other MAOIs (such as phenelzine, tranylcypromine), or other medications containing selegiline.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of selegiline tablets during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of selegiline tablets, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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