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  • Generic Name: (quetiapine fumarate)
    Other Brands: N/A
  • Last Revised: 07/2016
    • What is this medication and its most common uses?

      Seroquel XR is a medicine used to treat schizophrenia. Seroquel XR can also be used to treat bipolar disorder alone or in combination with lithium or divalproex. In addition, Seroquel XR is used to treat major depressive disorder in combination with other antidepressants.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      The symptoms of schizophrenia, bipolar disorder, and major depressive disorder are thought to be caused by chemical imbalances in the brain. Although it is unclear exactly how Seroquel XR works, it seems to help balance the chemicals in the brain, thereby helping to improve your symptoms.

      What are the beneficial effects of this medication and when should I begin to have results?


      Schizophrenia: Seroquel XR may relieve symptoms of schizophrenia as measured by a symptom rating scale that is commonly used by healthcare providers to evaluate the effectiveness of the medicine in people with this condition.

      Bipolar Disorder: Seroquel XR may effectively work for the short-term to treat three types of bipolar disorder episodes: mania (highs), mixed (highs and lows), and depression (lows).

      Major Depressive Disorder: Seroquel XR may be more effective than an antidepressant alone for treating unresolved symptoms of depression in people who have been on an antidepressant for 6 weeks or more.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Seroquel XR exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may ask you questions from time to time to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Seroquel XR is not approved to treat mental problems caused by dementia (an illness involving loss of memory and judgment, and confusion). It can be life-threatening when used in elderly people with mental problems caused by dementia.

      Seroquel XR can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening and suicidal/unusual behavior after you start taking Seroquel XR or start a new dose of Seroquel XR. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, or thoughts about suicide or dying; or if you have new symptoms or seem to be feeling worse.


      More common side effects may include: drowsiness, dry mouth, constipation, dizziness, increased appetite, upset stomach, weight gain, tiredness, difficulty speaking, nasal congestion.

      Children and Adolescents

      More common side effects may include: drowsiness, dizziness, tiredness, increased appetite, nausea, vomiting, dry mouth, rapid heartbeat, weight gain.

      Less common side effects of Seroquel XR may include:

      Neuroleptic malignant syndrome (NMS) (a life-threatening brain disorder) with symptoms such as high fever, excessive sweating, muscle rigidity, confusion, changes in your breathing, fast or irregular heartbeat, or changes in your blood pressure.

      High blood sugar with symptoms such as excessive thirst, an increase in urination, increased appetite, weakness, confusion, fruity smelling breath, or feeling sick to your stomach.

      Tardive dyskinesia, defined as abnormal muscle movements, including tremor, shuffling, and uncontrolled, involuntary movements.

      Sudden fall in blood pressure with symptoms such as dizziness, lightheadedness, or fainting when rising too quickly from a sitting or lying position.

      Low white blood cell counts with symptoms of an infection (such as fever, sore throat, rash, or chills).

      Development of cataracts with symptoms such as changes in your vision.

      Increased cholesterol (fats in your blood) and triglycerides (a type of blood fat), and weight gain.

      Increased blood pressure in children and teenagers.

    • Who should not take this medication?

      Do not take Seroquel XR if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Seroquel XR. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes, high cholesterol levels, high or low blood pressure, low white blood cell counts, cataracts, seizures, high prolactin (a hormone that can affect lactation, menstruation, and fertility) levels, or heart, liver, or thyroid problems; are pregnant; plan to become pregnant; or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


      Adults and adolescents 13-17 years: The recommended dose is 400-800 milligrams (mg) a day. Your healthcare provider may start you or your child on a lower dose and increase the dose as appropriate.

      Bipolar Mania

      Adults: The recommended dose is 400-800 mg a day. Your healthcare provider may start you on a lower dose and increase the dose as appropriate.

      Children and adolescents 10-17 years: The recommended dose is 400-600 mg a day. Your healthcare provider may start your child on a lower dose and increase the dose as appropriate.

      Bipolar Depression

      Adults: The recommended dose is 300 mg a day. Your healthcare provider may start you on a lower dose and increase the dose as appropriate.

      Maintenance Therapy of Bipolar Disorder

      Adults: The recommended dose is 400-800 mg a day.

      Major Depressive Disorder

      Adults: The recommended dose is 150-300 mg a day. Your healthcare provider may start you on a lower dose and increase the dose as appropriate.

      If you are elderly, have liver problems, or are taking certain medications, your healthcare provider may adjust your dose appropriately.

      It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

    • How should I take this medication?

      Take Seroquel XR exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Seroquel XR without first talking to your healthcare provider.

      Take Seroquel XR without food or with a light meal, preferably in the evening.

      Swallow Seroquel XR tablets whole. Do not split, chew, or crush them.

    • What should I avoid while taking this medication?

      Do not drink alcohol while you are taking Seroquel XR.

      Do not drive, operate machinery, or engage in other dangerous activities until you know how Seroquel XR affects you.

      Do not get overheated or dehydrated while you are taking Seroquel XR. Drink plenty of water and do not over-exercise. Stay out of the sun, and do not wear too much or heavy clothing. In hot weather, stay in a cool place if possible.

    • What are the possible food and drug interactions associated with this medication?

      If Seroquel XR is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Seroquel XR may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Seroquel XR may harm your newborn baby if you take it during the later stages of your pregnancy. Seroquel XR can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Seroquel XR. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Seroquel XR, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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