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Signifor is a medicine used to treat Cushing's disease (a hormone disorder) in people who have failed surgery or cannot have surgery. Signifor is administered as a subcutaneous (just below the skin) injection.
How does this medication work?
Signifor is thought to work by decreasing the amount of certain natural substances produced by the body, thereby improving your condition.
What are the beneficial effects of this medication and when should I begin to have results?
What: By decreasing levels of certain substances, Signifor may help improve Cushing's disease.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Signifor exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may perform certain blood tests to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: diarrhea, nausea, high blood sugar, gallstones, headache, abdominal (stomach area) pain, tiredness, diabetes.
Less common side effects may include:
Decreased blood cortisol levels, with symptoms such as weakness; tiredness; loss of appetite; nausea; vomiting; or decreased blood pressure, blood sodium levels, or blood sugar levels.
Changes in the electrical activity of your heart, with symptoms such as abnormal heartbeat, dizziness, or fainting.
Slow heart rate, with symptoms such as weakness, dizziness, or fainting.
Signifor may also increase your liver tests.
Do not use Signifor if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Signifor. Also, talk to your healthcare provider about your complete medical history, especially if you have high blood sugar levels; diabetes; heart, liver, or thyroid problems; low blood potassium or magnesium levels; gallstones; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended starting dose is either 0.6 or 0.9 milligrams twice a day. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.
If you have liver impairment, your healthcare provider may adjust your dose appropriately.
Use Signifor exactly as prescribed by your healthcare provider. Do not change your dose or stop using Signifor without first talking to your healthcare provider.
Signifor may be administered into the top of your thigh or abdomen. Rotate the injection sites with each dose.
Please review the instructions that came with your prescription on how to properly use Signifor.
Do not miss any scheduled follow-up appointments with your healthcare provider.
Do not inject Signifor into red or irritated skin.
Do not use Signifor if the solution changed color.
If Signifor is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Signifor with the following: blood pressure/heart medications known as beta-blockers (such as metoprolol or atenolol) and calcium channel blockers (such as amlodipine or diltiazem), bromocriptine, cyclosporine, or medicines that affect your heart rhythm (such as quinidine).
The effects of Signifor during pregnancy and breastfeeding are unknown. Do not breastfeed while you are using Signifor. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Signifor, use it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not use two doses at once.
Store at room temperature. Protect from light.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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