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  • Generic Name: (pasireotide)
    Other Brands: N/A
  • Last Revised: 12/2014
    • What is this medication and its most common uses?

      Signifor is a medicine used to treat Cushing's disease (a hormone disorder) in people who have failed surgery or cannot have surgery. Signifor is administered as a subcutaneous (just below the skin) injection.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Signifor is thought to work by decreasing the amount of certain natural substances produced by the body, thereby improving your condition.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By decreasing levels of certain substances, Signifor may help improve Cushing's disease.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you use Signifor exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may perform certain blood tests to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: diarrhea, nausea, high blood sugar, gallstones, headache, abdominal (stomach area) pain, tiredness, diabetes.

      Less common side effects may include:

      Decreased blood cortisol levels, with symptoms such as weakness; tiredness; loss of appetite; nausea; vomiting; or decreased blood pressure, blood sodium levels, or blood sugar levels.

      Changes in the electrical activity of your heart, with symptoms such as abnormal heartbeat, dizziness, or fainting.

      Slow heart rate, with symptoms such as weakness, dizziness, or fainting.

      Signifor may also increase your liver tests.

    • Who should not take this medication?

      Do not use Signifor if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Signifor. Also, talk to your healthcare provider about your complete medical history, especially if you have high blood sugar levels; diabetes; heart, liver, or thyroid problems; low blood potassium or magnesium levels; gallstones; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended starting dose is either 0.6 or 0.9 milligrams twice a day. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.

      If you have liver impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Use Signifor exactly as prescribed by your healthcare provider. Do not change your dose or stop using Signifor without first talking to your healthcare provider.

      Signifor may be administered into the top of your thigh or abdomen. Rotate the injection sites with each dose.

      Please review the instructions that came with your prescription on how to properly use Signifor.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not inject Signifor into red or irritated skin.

      Do not use Signifor if the solution changed color.

    • What are the possible food and drug interactions associated with this medication?

      If Signifor is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Signifor with the following: blood pressure/heart medications known as beta-blockers (such as metoprolol or atenolol) and calcium channel blockers (such as amlodipine or diltiazem), bromocriptine, cyclosporine, or medicines that affect your heart rhythm (such as quinidine).

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Signifor during pregnancy and breastfeeding are unknown. Do not breastfeed while you are using Signifor. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Signifor, use it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not use two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.