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  • Generic Name: (doxepin)
    Other Brands: N/A
  • Last Revised: 02/2015
    • What is this medication and its most common uses?

      Silenor is a sleep medicine used to treat insomnia, specifically in people who have trouble staying asleep.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Silenor works by decreasing the time you spend awake after falling asleep, thereby increasing your time asleep.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Silenor may help you stay asleep throughout the night.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Silenor exactly as your healthcare provider has prescribed.

      How do I know it is working?

      If you are able to fall asleep faster than you normally would and do not wake up as often during the night, Silenor is likely working effectively. Your healthcare provider may ask you questions from time to time to assess your sleep pattern.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: nausea, sleepiness, upper respiratory infection.

      Less common side effects may include:

      Abnormal thoughts and behavior, worsening of your depression, or suicidal thoughts or actions.

      Getting up out of bed while not being fully awake and engaging in activities that you do not know you are doing (such as driving a car ["sleep-driving"], making and eating food, talking on the phone, having sex, or sleep-walking).

    • Who should not take this medication?

      Do not use Silenor if you are allergic to it or any of its ingredients.

      Do not take Silenor if you are taking an antidepressant medication called a monoamine oxidase inhibitor (MAOI) (such as phenelzine) or have taken any within the past 14 days.

      Do not take Silenor if you have glaucoma (high pressure in the eye that is not being treated) or trouble urinating.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Silenor. Also, talk to your healthcare provider about your complete medical history, especially if you have liver or lung disease; severe sleep apnea (stopping breathing temporarily during sleep); a history of drug or alcohol abuse or addiction; depression, mental illness, or suicidal thoughts; or are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 6 milligrams (mg) once a day. If you are over 65 years of age, your healthcare provider may start you on a 3-mg once a day dose.

    • How should I take this medication?

      Take Silenor exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Silenor without first talking to your healthcare provider.

      Take Silenor within 30 minutes of bedtime. After taking it, you should confine your activities to those necessary to prepare for bed.

      Do not take Silenor within 3 hours of a meal. It may not work well, or may make you sleepy the next day if you take it with or right after a meal.

    • What should I avoid while taking this medication?

      Do not take Silenor unless you can get a full night of sleep before you must be active again.

      Do not drink alcohol while taking Silenor.

      Do not drive or engage in other activities that require complete alertness after taking Silenor until you feel fully awake.

    • What are the possible food and drug interactions associated with this medication?

      If Silenor is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Silenor with the following: alcohol, certain allergy medicines (antihistamines) or other medicines that can make you sleepy or affect your breathing, cimetidine or other medicines that can affect certain liver enzymes, MAOIs or tolazamide.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Silenor during pregnancy are unknown. Silenor can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Silenor, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.