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  • Generic Name: (osimertinib)
    Other Brands: N/A
  • Last Revised: 09/2016
    • What is this medication and its most common uses?

      Tagrisso is a medicine used to treat a certain type of non-small cell lung cancer when the cancer has spread to other parts of the body in people who have tried other medicines.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Tagrisso works by inhibiting the proteins responsible for the growth of cancer cells.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: By stopping the growth of cancer cells, Tagrisso may help to relieve symptoms associated with cancer.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Tagrisso exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order certain tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: diarrhea, rash, dry skin, changes in your nails (such as redness, tenderness, pain, or shedding of nails).

      Less common side effects may include:

      Lung problems, with symptoms such as trouble breathing, shortness of breath, cough, or fever.

      Heart problems, with symptoms such as feeling like your heart is pounding or racing, shortness of breath, swelling of your ankles and feet, or feeling lightheaded.

      Harm to your unborn baby. Tell your healthcare provider immediately if you are pregnant or plan to become pregnant.

    • Who should not take this medication?

      Do not take Tagrisso if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tagrisso. Also, talk to your healthcare provider about your complete medical history, especially if you have lung or breathing problems, heart problems (including a condition called long QTc syndrome), or problems with your electrolytes (such as sodium, potassium, calcium, or magnesium), or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended dose is 80 milligrams once a day.

      If you are taking certain other medicines, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Tagrisso exactly as prescribed by your healthcare provider.

      Take Tagrisso with or without food.

      If you have difficulty swallowing tablets, place the tablet in 60 milliliters (mL) (2 ounces) (oz) of non-carbonated water only. Stir until the tablet is in small pieces, and swallow immediately. Do not crush, heat, or use ultrasound to prepare the mixture. Add 120 to 240 mL (4 to 8 oz) of water into the container and drink to make sure that you take your full dose of Tagrisso.

    • What should I avoid while taking this medication?

      Do not change your dose or stop taking Tagrisso without first talking to your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Tagrisso is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Tagrisso may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      Tagrisso may harm your unborn baby if you take it during pregnancy. It is important that women who are able to become pregnant use effective birth control during treatment and for 6 weeks after the last dose of Tagrisso. Also, men with female partners who are able to become pregnant should use effective birth control during and for 4 months after the last dose. The effects of Tagrisso during breastfeeding are unknown. Do not breastfeed while you are taking Tagrisso and for 2 weeks after the last dose. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Tagrisso, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.