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Tasigna is an anticancer medicine used to treat certain types of leukemia in people who did not tolerate or are no longer benefitting from other treatments (including imatinib).
How does this medication work?
Tasigna works by inhibiting the proteins responsible for the growth of cancer cells and by improving normal blood cell counts.
What are the beneficial effects of this medication and when should I begin to have results?
What: Tasigna has been shown to be effective in treating certain types of leukemia.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Tasigna exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: nausea, rash, headache, tiredness, itching, vomiting, diarrhea, cough, constipation, muscle and joint pain, runny or stuffy nose, sneezing, sore throat, fever, night sweats.
Less common side effects may include:
Decreased blood flow to your legs, heart, or brain with symptoms such as chest pain or discomfort, numbness or weakness, problems walking or speaking, leg pain, cold legs, changes in the skin color of your legs.
Low blood cell counts with symptoms such as unexplained bleeding or bruising, blood in your urine or stool, unexplained weakness, and shortness of breath.
Serious heart rhythm changes, with symptoms such as fast or slow heartbeat, or fainting.
Liver problems with symptoms such as itching, yellowing of your skin or the whites of your eyes, dark-colored urine, and pain or discomfort in the right upper stomach area.
Pancreatitis (inflammation of your pancreas) with symptoms such as sudden stomach area pain with nausea and vomiting.
Bleeding in the brain with symptoms such as headache, changes in your eyesight, and loss of consciousness.
Tumor lysis syndrome (a condition caused by a sudden breakdown of cancer cells), which may lead to kidney problems and cause abnormal heartbeat.
Harm your unborn baby if taken during pregnancy. Contact your healthcare provider immediately if you believe or suspect you are pregnant while you are taking Tasigna.
Fluid retention with symptoms such as shortness of breath, rapid weight gain, and swelling.
Tasigna may also cause bleeding.
Do not take Tasigna if you are allergic to it or any of its ingredients.
Do not take Tasigna if you have low blood potassium or magnesium levels or if you have a heart condition called prolonged QT interval (very fast or abnormal heartbeats).
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Tasigna. Also, talk to your healthcare provider about your complete medical history, especially if you have heart problems, an irregular heartbeat (including prolonged QT interval); liver problems; low blood potassium or magnesium levels; have a history of stroke or other problems due to decreased blood flow to the brain or to your legs; bleeding problems; have had pancreatitis or a surgical removal of your stomach; if you are lactose intolerant; or are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: Your healthcare provider will prescribe the appropriate dose for you based on your condition and may increase your dose as needed, until the desired effect is achieved.
If you are taking certain other medicines or have liver impairment, your healthcare provider may adjust your dose appropriately.
Take Tasigna exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Tasigna without first talking to your healthcare provider.
Take Tasigna on an empty stomach, at least 1 hour before or at least 2 hours after a meal. Swallow Tasigna capsules whole with water.
If you cannot swallow Tasigna capsules whole, you may open the capsules and sprinkle the contents on 1 teaspoon of applesauce. Do not use more than 1 teaspoon of applesauce or sprinkle Tasigna onto other foods. Swallow the applesauce mixture right away within 15 minutes; do not store for future use.
Do not drink grapefruit juice, eat grapefruit, or take supplements containing grapefruit extract while you are taking Tasigna.
Do not become pregnant while you are taking Tasigna.
If Tasigna is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Tasigna may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
Tasigna may harm your unborn baby if you take it during pregnancy. Do not become pregnant or breastfeed while you are taking Tasigna. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Tasigna, skip the one you missed and return to your regular dosing scheduler. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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