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  • Generic Name: (tramadol hydrochloride)
    Other Brands: N/A
  • Last Revised: 02/2015
    • What is this medication and its most common uses?

      Ultram ER is a medicine used to treat long-term, moderate to severe around-the-clock pain. Ultram ER is an extended-release medicine (a type of tablet that releases medicine into your body throughout the day).

      Ultram ER is a federally controlled substance because it has abuse potential.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Ultram ER works in your central nervous system (the brain and spinal cord) and affects the way your body responds to pain.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Ultram ER has been shown to help relieve pain.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Ultram ER exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel an improvement in your pain. That is a good indicator that the medicine is working. Your healthcare provider may also ask you questions from time to time to assess how well your pain is controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: constipation; dizziness; nausea; drowsiness; headache; warm, hot, or burning feeling to your face.

      Less common side effects may include:

      Ultram ER has abuse potential. Mental and physical dependence can occur with the use of Ultram ER when it is used improperly.

      Serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells) with symptoms such as mental status changes (such as agitation or hallucinations), an increase in your heart rate and temperature, lack of coordination, overactive reflexes, muscle rigidity, nausea, vomiting, or diarrhea.

      Serious allergic reactions, with symptoms such as itching; hives; difficulty breathing; or swelling of your face, eyes, lips, and tongue.

      Ultram ER may also increase your risk of seizures or thoughts of suicide.

    • Who should not take this medication?

      Do not take Ultram ER if you are allergic to it, any of its ingredients, or to other pain medicines (such as codeine).

      Do not take Ultram ER if you drink alcohol frequently, or are currently taking other medicines that may make you sleepy or other painkillers.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ultram ER. Also, talk to your healthcare provider about your complete medical history, especially if you have severe kidney or liver problems; stomach or breathing problems; increased pressure in your head or head injury; an infection in your brain or spine; metabolic disorders (conditions that interfere with the process by which your body gets energy from food); a history of seizures, drug or alcohol abuse, or suicidal thoughts; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous pain medication.

      If you are elderly, your healthcare provider may adjust your dose appropriately.

      It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

    • How should I take this medication?

      Take Ultram ER exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

      Swallow Ultram ER tablets whole. Do not chew, crush, or split the tablets.

    • What should I avoid while taking this medication?

      Do not drink alcohol or take medicines that may make you sleepy while you are taking Ultram ER.

      Do not drive a car, operate machinery, or engage in other dangerous activities until you know how Ultram ER affects you.

    • What are the possible food and drug interactions associated with this medication?

      If Ultram ER is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Ultram ER with the following: carbamazepine, certain antidepressants (such as amitriptyline, fluoxetine, or paroxetine), certain migraine medicines (such as frovatriptan, sumatriptan, or zolmitriptan), digoxin, erythromycin, ketoconazole, linezolid, lithium, quinidine, rifampin, St. John's wort, or warfarin.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Ultram ER during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Ultram ER, skip the one you missed and return to your regular dosing schedule. Do not take two doses in 24 hours.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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