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  • Generic Name: (pancrelipase)
    Other Brands: N/A
  • Last Revised: 04/2015
    • What is this medication and its most common uses?

      Ultresa is a medicine that contains a mixture of digestive enzymes. Ultresa is a medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis (an inherited disease that causes your mucus to be thick and sticky, and may result in difficulty breathing) or other conditions determined by your healthcare provider. Ultresa is a delayed-release medicine (a capsule that releases medicine into your body at a later time from when you take it).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Ultresa replaces the digestive enzymes your pancreas is not producing, helping to digest nutrients (such as fats, proteins, and sugars) from food.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Ultresa may help improve the absorption of nutrients and fats from food.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Ultresa exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: headache, nosebleed, throat pain.

      Less common side effects may include:

      Increased chance of developing fibrosing colonopathy (a rare and serious bowel disorder), especially if used in high doses for long periods in people with cystic fibrosis. Tell your healthcare provider if you have any unusual or severe stomach pain, bloating, bowel movements, nausea, vomiting, or diarrhea.

      Irritation of the inside of your mouth, especially if Ultresa is retained in your mouth or is not swallowed completely.

      Increased blood uric acid levels that may worsen existing gout (severe and painful inflammation of the joints).

      Allergic reactions with symptoms such as trouble breathing, skin rash, itching, or swollen lips.

    • Who should not take this medication?

      Do not take Ultresa if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ultresa. Also, talk to your healthcare provider about your complete medical history, especially if you have gout, kidney problems, or a condition called high blood uric acid; trouble swallowing capsules; a history of intestinal blockage, or scarring or thickening of your bowel wall; or if you are allergic to pork (pig) products.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults and children: Your healthcare provider will prescribe the appropriate dose for you or your child based on the weight, and may adjust the dose as needed.

    • How should I take this medication?

      Take Ultresa exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Ultresa without first talking to your healthcare provider.

      Take Ultresa with meals or snacks.

      Give Ultresa to your child right before each feeding of formula or breast milk.

    • What should I avoid while taking this medication?

      Do not crush or chew Ultresa capsules. Swallow the capsules whole. If you are unable to swallow capsules, the capsules may be carefully opened and the contents sprinkled on a small amount of applesauce, yogurt, and certain other soft foods as directed by your healthcare provider. Swallow the soft food mixture immediately without crushing or chewing, and follow with water or juice to ensure complete ingestion.

      Do not mix Ultresa capsule contents directly into formula or breast milk. Open the capsule and sprinkle the contents on a small amount of soft acidic food such as applesauce, pureed bananas or pears or sprinkle the capsule contents directly into your infant's mouth and immediately give formula or breast milk. 

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Ultresa at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Ultresa during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Ultresa, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature, in a dry place. Protect from moisture. Avoid excessive heat.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.