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  • Generic Name: (dinutuximab)
    Other Brands: N/A
  • Last Revised: 04/2015
    • What is this medication and its most common uses?

      Unituxin is a medicine used in combination with other cancer medicine for the treatment of high-risk neuroblastoma (a type of brain tumor) in children who are partially responsive to first-line therapy. Unituxin is administered intravenously (injected into the vein).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Unituxin works by binding to cancer cells and killing them.

      What are the beneficial effects of this medication and when should I begin to have results?


      Unituxin has been shown in clinical studies to increase the length of event-free survival, which is defined as the time from the first relapse, progressive disease, secondary cancer, or death.


      Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Unituxin may cause serious and potentially life-threatening infusion reactions. Tell your healthcare provider immediately if you develop any signs or symptoms such as facial or lip swelling, urticaria, difficulty breathing, lightheadedness, or dizziness that occur during or within 24 hours following the infusion.

      Unituxin may cause severe nerve pain. Tell your healthcare provider immediately if you develop severe or worsening pain, numbness, tingling, burning, or weakness.

      More common side effects may include: pain, fever, low red blood cell counts, low white blood cell counts, low blood pressure, low blood salt levels, vomiting, diarrhea, low blood potassium and calcium levels.

      Less common side effects may include:

      Capillary leak syndrome (a syndrome characterized by massive leakage of plasma and other blood components from blood vessels) with symptoms such as swelling of the arms and legs, low blood pressure, weakness, tiredness, and nausea.

      Low blood cell counts with symptoms such as easy bruising or bleeding, infection, fever, paleness, or unusual tiredness.

      Unituxin may also cause infection, changes in your electrolyte (chemicals that are important for the cells in your body to function, such as sodium and potassium) levels, and kidney problems.

      Unituxin may cause harm to your unborn baby if received during pregnancy. Tell your healthcare provider immediately if you are or think you may be pregnant.

    • Who should not take this medication?

      Your healthcare provider will not administer Unituxin to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Unituxin. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney problems, low blood pressure, low blood cells, have an infection, or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Children: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her body weight and height.

    • How should I take this medication?

      Your healthcare provider will administer Unituxin to your child.

      Females who are of reproductive age should use effective contraception during treatment and for 2 months after the last dose of Unituxin.

    • What should I avoid while taking this medication?

      Do not miss any follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Unituxin at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      Unituxin may cause harm to your unborn baby if taken during pregnancy. The effects of Unituxin on breastfeeding are unknown. Do not breastfeed while receiving Unituxin. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Unituxin should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider or pharmacist for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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