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  • Generic Name: (bupropion hydrochloride)
    Other Brands: N/A
  • Last Revised: 05/2016
    • What is this medication and its most common uses?

      Wellbutrin SR is a medicine used to treat depression. Wellbutrin SR is a sustained-release medicine (a type of tablet that releases medicine into your body throughout the day).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Wellbutrin SR is thought to work by balancing the chemicals in your brain, thereby improving your symptoms of depression.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Wellbutrin SR may relieve symptoms of depression, as measured by appropriate symptom rating scales that are commonly used by healthcare providers to evaluate the effectiveness of the medicine in people with this condition.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Wellbutrin SR exactly as your healthcare provider has prescribed, even if you do not feel better right away.

      How do I know it is working?

      Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Wellbutrin SR can increase the risk of suicidal thoughts and behavior in children, teenagers, and young adults. Your healthcare provider will monitor you closely for clinical worsening and suicidal/unusual behavior after you start taking Wellbutrin SR or start a new dose of Wellbutrin SR. Tell your healthcare provider right away if you experience anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, or thoughts about suicide or dying; or if you have new symptoms or seem to be feeling worse.

      Bupropion (a component of Wellbutrin SR) may cause other changes in your behavior if you are taking it to help you quit smoking. Symptoms may include changes in your mood (including depression and mania), hallucinations (seeing or hearing things that are not there), agitation, aggression, suicidal thoughts or attempts, or paranoia (feeling that people are against you).

      More common side effects may include: headache, dry mouth, nausea, trouble sleeping, dizziness, sore throat, constipation, agitation, anxiety, abdominal (stomach area) pain, ringing in your ears, shakiness, fast heartbeat, muscle pain, sweating, rash, loss of appetite.

      Less common side effects may include:

      Manic episodes with symptoms such as greatly increased energy, severe trouble sleeping, racing thoughts, reckless behavior, unusually grand ideas, excessive happiness or irritability, or talking faster than usual.

      Unusual thoughts or behaviors, including delusions (believing you are someone else), hallucinations, paranoia, or feeling confused.

      Visual problems with symptoms such as eye pain, changes in vision, and swelling or redness in or around the eye.

      Serious allergic reactions, with symptoms such as itching; hives; difficulty breathing; or swelling of your face, lips, or tongue.

      Wellbutrin SR may also cause seizures or high blood pressure.

    • Who should not take this medication?

      Do not take Wellbutrin SR if you are allergic to it or any of its ingredients.

      Do not take Wellbutrin SR if you have a seizure disorder.

      Do not take Wellbutrin SR if you have an eating disorder (such as anorexia or bulimia).

      Do not take Wellbutrin SR if you drink excessive amounts of alcohol and suddenly stop drinking, or use medicines called sedatives (medicines that make you sleepy), benzodiazepines, or anti-seizure medicines, and you stop using them all of a sudden.

      Do not take Wellbutrin SR if you take another medicine called a monoamine oxidase inhibitor (MAOI) (such as phenelzine, selegiline, or linezolid), a class of medications used to treat depression and other conditions.
      Do not start taking Wellbutrin SR if you stopped taking an MAOI in the last 2 weeks, unless directed to do so by your healthcare provider.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Wellbutrin SR. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney problems, liver problems (including cirrhosis [scarring of the liver]), heart problems (including a heart attack), high blood pressure, eating disorders, a head injury, a tumor in your brain or spine, seizures, or diabetes; if you drink a lot of alcohol or abuse medicines; or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended starting dose is 150 milligrams once a day, in the morning. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

      If you have liver or kidney impairment, your healthcare provider may adjust your dose appropriately.

    • How should I take this medication?

      Take Wellbutrin SR exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Wellbutrin SR without first talking to your healthcare provider.

      Take Wellbutrin SR with or without food.

      If you are taking Wellbutrin SR more than once a day, take your doses of Wellbutrin SR at least 8 hours apart, as directed by your healthcare provider.

      Swallow Wellbutrin SR tablets whole. Do not chew, divide, or crush the tablets.

    • What should I avoid while taking this medication?

      Do not drive, operate heavy machinery, or do other dangerous activities until you know how Wellbutrin SR affects you.

      Do not drink alcohol while you are taking Wellbutrin SR. If you usually drink a lot of alcohol, talk with your healthcare provider before suddenly stopping.

      Do not take Wellbutrin SR if you are taking any other medicines that contain bupropion, including Zyban (used to help people stop smoking), Aplenzin, Forfivo XL, Wellbutrin, or Wellbutrin XL.

    • What are the possible food and drug interactions associated with this medication?

      If Wellbutrin SR is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Wellbutrin SR may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Wellbutrin SR during pregnancy are unknown. Wellbutrin SR can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Wellbutrin SR, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once and do not take an extra dose to make up for the dose you forgot.

    • How should I store this medication?

      Store at room temperature. Protect from light and moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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