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  • Generic Name: (rivaroxaban)
    Other Brands: N/A
  • Last Revised: 10/2016
    • What is this medication and its most common uses?

      Xarelto is a medicine used to reduce the risk of stroke and blood clots in people with atrial fibrillation (an irregular, fast heartbeat). Xarelto is also used to treat deep vein thrombosis (DVT) (a blood clot in the legs) and pulmonary embolism (PE) (a blood clot in the lungs) and to help reduce the risk of these conditions occurring again. In addition, Xarelto is used to reduce the risk of DVT and PE in people who have just had a knee or hip replacement surgery.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Xarelto works by stopping the formation of blood clots.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Xarelto reduces the risk of stroke associated with atrial fibrillation, as well as treats and helps prevent DVT and PE with no regular blood monitoring.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Xarelto exactly as your healthcare provider has prescribed.

      How do I know it is working?

      Your healthcare provider may order tests regularly to check how well this medication is working.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      If you take Xarelto and receive spinal anesthesia or have a spinal puncture, you may be at increased risk of developing a blood clot that can cause paralysis (a loss of ability to move). Your risk of developing a spinal or epidural blood clot is higher if a thin tube called an epidural catheter is placed in your back to give you certain medicine, if you take certain medicines to prevent blood from clotting, if you have a history of difficult or repeated epidural or spinal punctures, or if you have a history of problems with your spine or have had surgery on your spine. Tell your healthcare provider right away if you experience back pain, tingling, numbness, or weakness in your legs and feet; or trouble urinating.

      Stopping Xarelto suddenly can increase the risk of having a stroke or blood clots. Do not stop taking Xarelto without first talking to your healthcare provider, even if you feel well.

      More common side effects may include: bleeding.

      Less common side effects may include:

      Serious and possibly life-threatening bleeding, especially if you take other medicines that increase your risk of bleeding (such as aspirin, clopidogrel, heparin, nonsteroidal anti-inflammatory drugs [such as ibuprofen or naproxen], selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, or warfarin), with symptoms such as frequent nose bleeds; unusual bleeding from your gums; heavier than normal menstrual bleeding; bleeding that is severe or uncontrollable; red, pink, or brown urine; bright red or black stools; coughing up blood or blood clots; vomiting blood or vomit that looks like coffee grounds; headaches; feeling dizzy or weak; or pain, swelling, or new drainage at wound sites.

    • Who should not take this medication?

      Do not take Xarelto if you are allergic to it or any of its ingredients.

      Do not take Xarelto if you currently have abnormal bleeding (such as stomach or intestinal bleeding, or bleeding in your head).

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Xarelto. Also, talk to your healthcare provider about your complete medical history, especially if you have bleeding problems; liver or kidney problems; an artificial heart valve; if you are scheduled for surgery (including a dental procedure); or if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Prevention of Stroke and Blood Clots in Atrial Fibrillation

      Adults: The recommended dose is 15 milligrams (mg) or 20 mg once a day with the evening meal.

      Treatment of DVT and PE

      Adults: The recommended starting dose is 15 mg twice a day. Your healthcare provider may adjust your dose as needed for maintenance treatment.

      Reduction in the Risk of DVT and PE Reoccurring

      Adults: The recommended dose is 20 mg once a day.

      Prevention of DVT Following Hip Replacement Surgery

      Adults: The recommended dose is 10 mg once a day for 35 days.

      Prevention of DVT Following Knee Replacement Surgery

      Adults: The recommended dose is 10 mg once a day for 12 days.

    • How should I take this medication?

      Take Xarelto exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Xarelto without first talking to your healthcare provider.

      If you are taking the 15-mg or 20-mg Xarelto tablets, take the medicine with food. If you are taking the 10-mg tablets, you can take them with or without food.

      If you have difficulty swallowing Xarelto tablets whole, talk to your healthcare provider about other ways to take Xarelto.

      Your healthcare provider may stop Xarelto for a short time before any surgery or medical or dental procedure and will tell you when to start taking Xarelto again after your surgery or procedure.

    • What should I avoid while taking this medication?

      Do not run out of Xarelto. Refill your prescription of Xarelto before you run out.

    • What are the possible food and drug interactions associated with this medication?

      If Xarelto is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Xarelto may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Xarelto during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Xarelto. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Once-a-Day Dosing

      If you are taking Xarelto once a day and you miss your dose, take the missed dose as soon as you remember and return to your regular dosing schedule the following day. Do not take two doses at once.

      Twice-a-Day Dosing

      If you are taking Xarelto twice a day and you miss your dose, take the missed dose as soon as you remember. This means you may take two doses at the same time to make up for the missed dose. Return to your regular dosing schedule the following day.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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