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  • Generic Name: (incobotulinumtoxinA)
    Other Brands: N/A
  • Last Revised: 01/2016
    • What is this medication and its most common uses?

      Xeomin is a medicine used to treat cervical dystonia (a movement disorder characterized by the pulling of the neck and shoulder muscles). Xeomin is also used to improve the look of moderate to severe frown lines between the eyebrows for a short period of time. In addition, Xeomin is used to treat abnormal spasms of the eyelids in people who have been previously treated with Botox. Xeomin is also used to treat upper limb spasticity. Xeomin is available as an intramuscular injection (injected directly into the muscle).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Xeomin works by reducing nerve stimulation to the injected muscles, thereby decreasing muscle activity.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Xeomin may help decrease neck pain or stiffness in the arm, reduce eyelid spasms, and improve the appearance of frown lines.

      When: Xeomin may begin to demonstrate its effects within 7 days after injection.

      How do I know it is working?

      You may notice an improvement in your condition or the appearance of your frown lines after you start receiving Xeomin. Your healthcare provider may ask you a series of questions from time to time that will help assess how well you are responding to treatment.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      In some cases, the effects of Xeomin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. Symptoms include trouble swallowing, speaking, or breathing; loss of strength and muscle weakness all over your body; double vision, blurred vision, or drooping eyelids; hoarseness or change or loss of your voice; trouble speaking clearly; or loss of your bladder control. These may be symptoms of botulism and can occur hours to weeks after you receive an injection of Xeomin.

      More common side effects for the treatment of upper limb spasticity may include: seizures, common cold, dry mouth, upper respiratory infection.

      More common side effects for the treatment of cervical dystonia may include: difficulty swallowing, neck pain, muscle weakness, injection-site pain, muscle and joint pain.

      More common side effects for the treatment of abnormal eyelid spasms may include: drooping eyelid, dry eyes, dry mouth, diarrhea, headache, changes in vision, difficulty breathing, common cold, respiratory infection.

      More common side effects for the treatment of frown lines may include: headache.

      Less common side effects of Xeomin may include:

      Xeomin may also cause reduced blinking or effectiveness of blinking.

    • Who should not take this medication?

      Your healthcare provider will not administer Xeomin to you if you are allergic to it, any of its ingredients (including human albumin or sucrose), or to other similar medications (such as Botox, Dysport, or Myobloc).

      Your healthcare provider will not administer Xeomin to you if you have an infection at the site to be injected.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Xeomin. Also, talk to your healthcare provider about your complete medical history, especially if you have a disease that affects your muscles and nerves (such as Lou Gehrig's disease, myasthenia gravis [loss of muscular control], or Lambert-Eaton syndrome); have breathing problems (such as asthma or emphysema); have a history of swallowing problems or inhaling food or fluid into your lungs; have bleeding problems; have drooping eyelids; if you have had surgery on your face or are scheduled for surgery; or if you had any side effect from any other botulinum toxin in the past.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you, based on your condition.

    • How should I take this medication?

      Your healthcare provider will administer Xeomin to you.

    • What should I avoid while taking this medication?

      Do not drive, operate heavy machinery, or engage in other dangerous activities until you know how Xeomin affects you.

      Do not miss any scheduled follow-up appointments with your healthcare provider.

    • What are the possible food and drug interactions associated with this medication?

      If Xeomin is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Xeomin with the following: anticholinergics (such as diphenhydramine or oxybutynin), certain antibiotics (such as gentamicin or neomycin), muscle relaxants (such as carisoprodol and cyclobenzaprine), or other medications containing the similar ingredient as Xeomin (such as Botox, Dysport, and Myobloc).

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Xeomin during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Xeomin should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
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