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  • Generic Name: (omalizumab)
    Other Brands: N/A
  • Last Revised: 07/2016
    • What is this medication and its most common uses?

      Xolair is a medicine used to treat moderate to severe persistent allergic asthma in people who have had a skin or blood test that is positive for allergic asthma and whose symptoms are not controlled by asthma medications called inhaled corticosteroids. Xolair is also used to treat chronic (long-term) hives in people who are not controlled by antihistamine treatment. Xolair is administered subcutaneously (just below the skin).

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Xolair works by blocking certain substances in your body that are involved in an allergic reaction.

      This medication is not used to treat other allergic conditions and is not for emergency or immediate treatment of symptoms of asthma. Always have a short-acting rescue inhaler (such as albuterol) to treat sudden symptoms.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Xolair helps reduce the number of asthma attacks in people with allergic asthma. Xolair has been shown to reduce the itchiness of hives and the number of hives in people with chronic hives.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's direction. It is important that you use Xolair exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel improvement in your symptoms. Your healthcare provider may also perform tests and ask you questions to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      Serious and life-threatening allergic reactions may occur after receiving Xolair. The allergic reaction can occur after the first dose or after many doses. Your healthcare provider will monitor you closely for symptoms while you receive Xolair and for a period of time after your injection. Tell your healthcare provider right away if you experience wheezing, shortness of breath, cough, chest tightness, trouble breathing, low blood pressure, dizziness, fainting, rapid or weak heartbeat, anxiety, flushing, itching, hives, feeling warm, swelling of your throat or tongue, throat tightness, hoarse voice, or trouble swallowing.

      More common side effects in children 6 to <12 years with allergic asthma may include: swelling of the inside of your nose and throat, headache, fever, sore throat, earache, pain in the stomach area, nausea, vomiting, nose bleeds.

      More common side effects in adults and children ≥12 years with allergic asthma may include: pain, joint pain, pain in your arms and legs, tiredness, dizziness, earache, skin rash, itching, bone fractures.

      More common side effects in people with chronic hives may include: nausea, joint pain, headache, cough, upper respiratory infection, swelling of the inside of your nose, throat, or sinuses.

      Less common side effects of Xolair may include:

      Increased risk of developing certain types of cancer.

      Chest pain, heart attack, blood clots in the lungs or legs, or temporary weakness on one side of the body, slurred speech, or vision changes in some people.

      Fever, joint pain, and rash 1 to 5 days after receiving Xolair.

      Parasitic infections in some people who are at high risk for parasite infections.

    • Who should not take this medication?

      Your healthcare provider will not administer Xolair to you if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Xolair. Also, talk to your healthcare provider about your complete medical history, especially if you have other types of allergies (such as food or seasonal allergies), have breathing problems, had a severe allergic reaction known as anaphylaxis, have or have had a parasitic infection or cancer, are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Allergic Asthma

      Adults and children ≥6 years: The usual dose is 75-375 milligrams (mg) every 2-4 weeks.

      Chronic Hives

      Adults and children ≥12 years: The usual dose is 150 or 300 mg every 4 weeks.

    • How should I take this medication?

      Your healthcare provider will administer Xolair to you.

    • What should I avoid while taking this medication?

      Do not miss any scheduled follow-up appointments with your healthcare provider.

      Do not decrease or stop taking any of your other asthma or hive medicines unless your healthcare provider tells you to do so.

    • What are the possible food and drug interactions associated with this medication?

      No significant interactions have been reported with Xolair at this time. However, always tell your healthcare provider about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Xolair during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      Xolair should be given under special circumstances determined by your healthcare provider. If you miss your scheduled dose, contact your healthcare provider for advice.

    • How should I store this medication?

      Your healthcare provider will store this medication for you.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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