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  • Generic Name: (tizanidine hydrochloride)
    Other Brands: N/A
  • Last Revised: 03/2014
    • What is this medication and its most common uses?

      Zanaflex is a medicine used to manage muscle spasms. Zanaflex is available as capsules and tablets.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Zanaflex works by relaxing your muscles, thereby relieving symptoms associated with muscle spasms.

      What are the beneficial effects of this medication and when should I begin to have results?

      What: Zanaflex has been shown to reduce the frequency of muscle spasms.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Zanaflex exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may feel a relief in your muscle spasms after you take Zanaflex. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: dry mouth, drowsiness, weakness, dizziness, urinary tract infection, constipation, increased or abnormal liver function tests, vomiting, speech problems, lazy eye, increased urination, flu syndrome, uncontrollable movements of the upper body or extremities, nervousness, sore throat, inflammation of the lining of the nose.

      Less common side effects may include:

      Sudden fall in blood pressure with symptoms such as dizziness, lightheadedness, or fainting when rising too quickly from a sitting or lying position.

      Liver problems with symptoms such as nausea or vomiting, loss of appetite, or yellowing of your skin or the whites of your eyes.

      Zanaflex may also cause hallucinations.

    • Who should not take this medication?

      Do not take Zanaflex if you are allergic to it or any of its ingredients.

      Do not take Zanaflex if you take a medicine called fluvoxamine or ciprofloxacin.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zanaflex. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: The recommended starting dose is 2 milligrams every 6 to 8 hours as needed. Do not take more than 3 doses in 24 hours.

      Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

      It is important that you do not stop taking this medication abruptly. If you need to change or stop taking this medication, it is important that you only do this with the guidance of your healthcare provider.

    • How should I take this medication?

      Take Zanaflex exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Zanaflex without first talking to your healthcare provider.

      Take Zanaflex the same way, either with or without food every day.

    • What should I avoid while taking this medication?

      Do not drive, operate heavy machinery, or engage in other dangerous activities until you know how Zanaflex affects you.

    • What are the possible food and drug interactions associated with this medication?

      If Zanaflex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Zanaflex with the following: acyclovir, alcohol, birth control pills, blood pressure and anxiety medications known as alpha adrenergic agonists (such as guanfacine), certain antibiotics (such as ciprofloxacin or levofloxacin), cimetidine, famotidine, fluvoxamine, medications that slow down your brain function (such as oxycodone or alprazolam), medicines that affect your heart rhythm (such as amiodarone or verapamil), ticlopidine, or zileuton.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Zanaflex during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Zanaflex, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
      back to top Use your PDR® Pharmacy Discount Card when you or a family member fills a prescription and ask for your PDR® Discount every
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    This discount plan is NOT insurance or a Medicare prescription drug plan. The plan is not intended as a substitute for insurance and does not meet creditable coverage requirements under state or federal law. The plan provides discounts at participating pharmacies on certain pharmaceutical supplies, prescription drugs, or medical equipment and supplies. The range of discounts will vary depending on the products received. Members are obligated to pay the pharmacy the entire amount of the discounted rate for such products at the point of sale. The plan does not pay pharmacies for products provided to members. No enrollment or periodic fees apply. The pharmacy may pay the plan a fee from amounts the pharmacy collects from the member. The discount plan organization is ProCare Pharmacy Benefit Manager, Inc.,1267 Professional Parkway, ProCare Office Park, Gainesville, GA 30507, 1-888-299-5383. Customer service is provided by PDR, LLC., 5 Paragon Drive, Montvale, NJ, 07645, 1-800-232-7379, www.pdr.net/DiscountCard, customerservice@pdr.net.