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  • Generic Name: (omeprazole/sodium bicarbonate)
    Other Brands: N/A
  • Last Revised: 08/2016
    • What is this medication and its most common uses?

      Zegerid is a medicine known as a proton pump inhibitor (PPI) that is used to treat duodenal ulcers (ulcers in the upper intestine) and stomach ulcers, as well as heartburn and other symptoms associated with gastroesophageal reflux disease (GERD). Zegerid is also used to treat erosive esophagitis (acid-related damage to the lining of the esophagus [the tube that connects your mouth and stomach]) and maintain healing of the esophagus. Additionally, Zegerid is used to lower the risk of stomach bleeding in critically ill people. Zegerid is also available as capsules and powder for an oral suspension.

    • What should I know when beginning and continuing on this medication?

      How does this medication work?

      Zegerid contains two medicines: omeprazole and sodium bicarbonate. Omeprazole is a PPI that works by decreasing the amount of acid in the stomach. Sodium bicarbonate works by protecting omeprazole from being broken down by acid in the stomach.

      What are the beneficial effects of this medication and when should I begin to have results?


      Duodenal and Stomach Ulcers: Zegerid may help heal duodenal and stomach ulcers, thereby relieving pain associated with these conditions.

      GERD: Zegerid may relieve symptoms such as heartburn.

      Erosive Esophagitis: Zegerid may help heal erosive esophagitis and prevent it from coming back.

      Reduction of Risk of Stomach Bleeding in Critically Ill Patients: Zegerid may help prevent stomach bleeding in people who are critically ill.

      When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's instructions. It is important that you take Zegerid exactly as your healthcare provider has prescribed.

      How do I know it is working?

      You may start to notice a reduction in the severity or frequency of your heartburn. This is a good indicator that your medication is working. Your healthcare provider will ask you questions from time to time to assess how well your condition is controlled.

    • What are the possible side effects of this medication?

      The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

      More common side effects may include: headache, abdominal (stomach area) pain, nausea, diarrhea, vomiting, gas.

      Less common side effects may include:

      Increased risk of severe diarrhea that may be caused by an infection in your intestines, with symptoms such as watery stools, stomach pain, and fever that does not go away.

      People who take multiple daily doses of PPI medicines for a long period of time (a year or longer) may have an increased risk of fractures of the hip, wrist, or spine.

      Chronic (long-term) inflammation of the stomach lining with symptoms such as stomach pain, nausea, vomiting, or weight loss.

      Low blood magnesium levels with symptoms such as seizures, dizziness, abnormal or fast heartbeat, jitteriness, jerking movements or shaking, muscle weakness, spasms of the hands and feet, cramps or muscle aches, or spasm of the voice box.

      Zegerid may also cause vitamin B12 deficiency. Talk to your healthcare provider about the possibility of vitamin B12 deficiency if you have been taking Zegerid for more than 3 years.

    • Who should not take this medication?

      Do not take Zegerid if you are allergic to it or any of its ingredients.

    • What should I tell my healthcare provider before I take the first dose of this medication?

      Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zegerid. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems, heart failure, Bartter's syndrome (a rare kidney disorder), or any allergies; have been told you have low magnesium, calcium, or potassium levels in your blood; or are pregnant, breastfeeding, or planning to become pregnant.

    • What is the usual dosage?

      The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

      Adults: Your healthcare provider will prescribe the appropriate dose for you, based on the condition being treated.

    • How should I take this medication?

      Take Zegerid exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Zegerid without first talking your healthcare provider.

      Take Zegerid on an empty stomach, at least 1 hour before food.

      Swallow Zegerid capsules whole with water. Do not use other liquids. Do not crush, chew, or open the capsules.

      If you take Zegerid oral suspension, empty the contents of a packet into a small cup containing 1 to 2 tablespoons of water. Do not use other liquids or foods. Stir well and drink right away. Refill cup with water and drink.

    • What should I avoid while taking this medication?

      Do not substitute two 20-milligram (mg) packets of Zegerid powder for oral suspension for one 40-mg packet, or two 20-mg capsules of Zegerid for one 40-mg capsule; if you do so, you will receive twice the amount of sodium bicarbonate.

    • What are the possible food and drug interactions associated with this medication?

      If Zegerid is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Zegerid may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.

    • May I receive this medication if I am pregnant or breastfeeding?

      The effects of Zegerid during pregnancy are unknown. Zegerid can be found in your breast milk if you take it while breastfeeding. Do not breastfeed while you are taking Zegerid. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    • What should I do if I miss a dose of this medication?

      If you miss a dose of Zegerid, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

    • How should I store this medication?

      Store at room temperature. Protect from light and moisture.

    • Who should I contact in case of emergency or overdose?
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      In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
      National Poison Control#: Call 1-800-222-1222

      This PDR+ drug information has been developed by the Physicians’ Desk Reference Network (PDRN), a source of medication information trusted by doctors for over 65 years.

      This monograph summarizes the most important information about your medication and does not cover all the information you may need. If you have any questions or concerns or want to learn more about your medication, ask your healthcare provider; he/she will be able to provide answers to your questions. This medication should only be used by the patient for whom it was prescribed and should not be shared with other people.
    • Additional patient resources.
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