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Zelapar is a medicine called a monoamine oxidase inhibitor (MAOI). It is used in combination with levodopa/carbidopa to treat signs and symptoms of Parkinson's disease.
How does this medication work?
Zelapar is thought to work by increasing the activity of a chemical in your brain called dopamine. By increasing dopamine activity, Zelapar may help improve symptoms of Parkinson's disease.
What are the beneficial effects of this medication and when should I begin to have results?
What: Zelapar has been shown to reduce symptoms associated with Parkinson's disease, such as uncontrolled movements.
When: You may begin to see an improvement in your condition after about 1 week of starting Zelapar. It is important that you take Zelapar exactly as your healthcare provider has prescribed, even if you do not feel better right away.
How do I know it is working?
Your healthcare provider may ask you a series of questions from time to time that will help assess how well your symptoms are controlled with treatment.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: dizziness, nausea, pain, headache, trouble sleeping, runny nose, involuntary muscle movements, back pain, sore mouth, indigestion.
Less common side effects may include:
Sudden fall in your blood pressure with symptoms such as dizziness, lightheadedness, or fainting when rising too quickly from a sitting or lying position.
Urges to behave in a way unusual for you, such as unusual urges to gamble or increased sexual urges and behaviors.
Oral irritation with symptoms such as swallowing pain, and reddening or swelling in your mouth.
If you are also taking levodopa, Zelapar may make some side effects of levodopa worse, such as causing uncontrolled sudden movements or make such movement you already have worse.
Neuroleptic malignant syndrome (a life-threatening brain disorder) with symptoms such as high fever, excessive sweating, muscle rigidity, confusion, changes in your breathing, fast or irregular heartbeat, or changes in your blood pressure.
Zelapar may also cause hallucinations (seeing or hearing things that are not really there).
Do not take Zelapar if you are allergic to it or any of its ingredients.
Do not take Zelapar if you are currently taking meperidine, methadone, propoxyphene, or tramadol or if you have stopped taking these medications in the last 14 days.
Do not take Zelapar if you are taking dextromethorphan.
Do not take Zelapar if you are currently taking another MAOI such as phenelzine or have stopped taking an MAOI within the past 14 days.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zelapar. Also, talk to your healthcare provider about your complete medical history, especially if you have kidney or liver problems; a condition known as phenylketonuria (an inability to process phenylalanine, a protein in your body); a history of skin cancer or mental disorder; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended starting dose is 1.25 milligrams (mg) once a day. Do not take more than 2.5 mg per day. Your healthcare provider may adjust your dose as needed, until the desired effect is achieved.
Take Zelapar exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Zelapar without first talking to your healthcare provider.
Take Zelapar in the morning before breakfast and without liquid.
Only remove the blister from the outer pouch when you are ready to take Zelapar. Peel back the backing with dry hands and gently remove the tablet. Place the tablet on top of your tongue immediately and let it dissolve. Do not eat any food or drink any liquids for 5 minutes before and after you take Zelapar.
It is important that you follow any dietary recommendations your healthcare provider gives you.
Do not drive a car, operate heavy machinery, or engage in other dangerous activities until you know how Zelapar affects you.
Do not eat excessive amounts of tyramine-containing foods (such as aged cheese) while you are taking Zelapar.
If Zelapar is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Zelapar may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
The effects of Zelapar during pregnancy and breastfeeding are unknown. Do not breastfeed while you are taking Zelapar. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Zelapar, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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