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Zelboraf is an anticancer medicine used to treat a certain type of skin cancer called melanoma that has spread to other parts of the body or cannot be removed by surgery.
How does this medication work?
Zelboraf is thought to work by slowing down the growth of cancer cells.
What are the beneficial effects of this medication and when should I begin to have results?
What: Zelboraf helped patients live longer, helped patients' tumors shrink, and helped control patients' disease.
When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Zelboraf exactly as your healthcare provider has prescribed.
How do I know it is working?
Your healthcare provider may order tests regularly to check how well this medication is working.
The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: joint pain, rash, hair loss, tiredness, sunburn or sun sensitivity, nausea, itching, warts.
Less common side effects may include:
A type of skin cancer called cutaneous squamous cell carcinoma, new melanoma lesions, and another type of cancer called non-cutaneous squamous cell carcinoma. Talk with your healthcare provider about your risk for these cancers.
Serious allergic reactions, with symptoms such as rash or redness all over your body; trouble breathing or swallowing; swelling of the face, lips, or tongue; throat tightness or hoarseness; feeling faint; or a fast heartbeat.
Severe skin reactions with symptoms such as blisters on your skin or in your mouth, peeling of your skin, fever, redness or swelling of your face, hands, or soles of your feet.
Changes in the electrical activity of your heart called QT prolongation (very fast or abnormal heartbeats), with symptoms such as feeling faint, lightheaded, dizzy; or feeling your heart beating irregularly or fast.
Liver problems with symptoms such as itching, yellowing of your skin or the whites of your eyes, dark-colored urine, tiredness, loss of appetite, nausea, vomiting, and pain or discomfort in the right upper stomach area.
Eye problems with symptoms such as blurred vision or eye pain, swelling, or redness.
Worsening side effects from radiation treatment.
Harm to your unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant.
Kidney injury. Your healthcare provider will perform blood tests to check your kidney function before you start therapy and during treatment.
Do not take Zelboraf if you are allergic to it or any of its ingredients.
Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zelboraf. Also, talk to your healthcare provider about your complete medical history, especially if you have liver, kidney, or heart problems (including long QT syndrome); have low blood potassium, calcium, or magnesium levels; have had or are planning to receive radiation therapy; or if you are pregnant, plan to become pregnant, or are breastfeeding.
The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Adults: The recommended dose is 960 milligrams (mg) (four 240-mg tablets) every 12 hours.
Take Zelboraf exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Zelboraf without first talking to your healthcare provider.
Take Zelboraf with or without a meal.
Take Zelboraf tablets whole. Do not crush or chew the tablets.
If you vomit after taking a dose of Zelboraf, do not take an additional dose. Continue with your next scheduled dose as directed by your healthcare provider.
Do not expose yourself to direct sunlight, and try to limit your time in the sun, as Zelboraf can increase your sensitivity to light. If you need to be outdoors, use lip balm and a broad-spectrum sunscreen with SPF 30 or higher and wear clothes that protect your skin from the sun.
If Zelboraf is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Zelboraf may interact with numerous medications. Therefore, it is very important that you tell your healthcare provider about any other medications you are taking.
Zelboraf can harm your unborn baby if taken during pregnancy. Women who are able to become pregnant should use effective birth control during treatment with Zelboraf and for 2 weeks after the final dose. The effects of Zelboraf during breastfeeding are unknown. Do not breastfeed during treatment with Zelboraf and for 2 weeks after the final dose. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
If you miss a dose of Zelboraf, take it as soon as you remember. However, if it is within 4 hours of your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
Store at room temperature.
In the event of a medical emergency call your doctor or 9-1-1 immediately. In the event of overdose, call your doctor or poison control for further instructions.
National Poison Control#: Call 1-800-222-1222
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