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Cardene IV Premixed
Calcium channel blocker (dihydropyridine)
Short-term treatment of HTN when oral therapy is not feasible or not desirable.
Adults: Individualize dose. Patients Not Receiving Oral Nicardipine: Initial: 5mg/hr IV infusion. Titrate: May increase by 2.5mg/hr every 5 min (for rapid titration) to 15 min (for gradual titration) if desired BP reduction is not achieved. Max: 15mg/hr. Decrease infusion rate to 3mg/hr after BP goal achieved with rapid titration. Equivalent Oral Dose to IV Dose: 20mg q8h=0.5mg/hr; 30mg q8h=1.2mg/hr; 40mg q8h=2.2mg/hr. Transition to PO Nicardipine: Give 1st dose 1 hr prior to discontinuation of infusion. Hepatic Impairment/Reduced Hepatic Blood Flow: Consider lower dosages. Renal Impairment/Heart Failure: Titrate gradually. Elderly: Use low initial doses. (Premixed) Impending Hypotension/Tachycardia: D/C then restart at 3-5mg/hr when BP has stabilized and adjust to maintain desired BP.
IV route. Refer to PI for preparation and administration instructions.
Inj: 2.5mg/mL [10mL], 0.1mg/mL [200mL], 0.2mg/mL [200mL]
Advanced aortic stenosis.
May induce or exacerbate angina in coronary artery disease (CAD) patients. Caution with heart failure (HF) or significant left ventricular dysfunction. To reduce possibility of venous thrombosis, phlebitis, local irritation, swelling, extravasation, and occurrence of vascular impairment, administer through large peripheral or central veins; change IV site q12h to minimize risk of peripheral venous irritation. May occasionally produce symptomatic hypotension or tachycardia. Avoid systemic hypotension when administering in sustained acute cerebral infarction or hemorrhage. Caution in hepatic/renal impairment, reduced hepatic blood flow, and in elderly.
Headache, hypotension, tachycardia, N/V.
Titrate slowly with β-blockers in HF or significant left ventricular dysfunction due to possible negative inotropic effects. Increased nicardipine levels when oral nicardipine is given with cimetidine; frequently monitor response. Elevated cyclosporine levels reported with oral nicardipine; closely monitor cyclosporine levels and reduce its dose accordingly.
Category C, not for use in nursing.
Calcium channel blocker (dihydropyridine); inhibits transmembrane influx of Ca2+ ions into cardiac muscle and smooth muscles without changing serum Ca2+ concentrations.
Distribution: Vd=8.3L/kg; plasma protein binding (>95%); found in breast milk. Metabolism: Liver (extensive). Elimination: Urine (49%), feces (43%); T1/2=14.4 hrs.
Assess for advanced aortic stenosis, HF, CAD, left ventricular dysfunction, sustained acute cerebral infarction or hemorrhage, hepatic/renal impairment, pregnancy/nursing status, and possible drug interactions.
Monitor for symptomatic hypotension, tachycardia, induction or exacerbation of angina, and other adverse reactions. Monitor BP and HR during administration. Closely monitor responses with impaired liver function or reduced hepatic blood flow.
Advise to seek medical attention if adverse reactions occur.
20-25°C (68-77°F). Avoid excessive heat. Protect from light. Diluted Sol: Stable at room temperature for 24 hrs. Premixed: Protect from freezing.