Not a Member?
Email this page
Send the page ""
to a friend, relative, colleague or yourself.
Separate multiple email address with a comma
We do not record any personal information entered above.
Thank you. Your email has been sent.
Enroll today in the free PDR Pharmacy Discount Card Program and help your patients save
Cephalosporin (1st generation)
Treatment of respiratory tract, urinary tract, skin and skin structure, biliary tract, bone and joint, and genital infections, septicemia, and endocarditis caused by susceptible strains of microorganisms. Perioperative prophylaxis for surgical procedures classified as contaminated or potentially contaminated.
Adults: Moderate to Severe Infections: 500mg-1g q6-8h. Mild Gram-Positive Cocci Infection: 250-500mg q8h. Acute, Uncomplicated UTI: 1g q12h. Pneumococcal Pneumonia: 500mg q12h. Severe Life-Threatening Infection (eg, Endocarditis, Septicemia): 1-1.5g q6h; Max: 12g/day (rare). Perioperative Prophylaxis: 1g IV 0.5-1 hr before surgery. For Procedures ≥2 hrs: 500mg-1g IV during surgery. Maint: 500mg-1g IV q6-8h for 24 hrs postop. Continue for 3-5 days postop for surgeries where occurrence of infection may be particularly devastating (eg, open-heart surgery, prosthetic arthroplasty). Renal Impairment: CrCl 35-54mL/min or SrCr of 1.6-3mg/dL: Full dose q8h. CrCl 11-34mL/min or SrCr of 3.1-4.5mg/dL: 1/2 usual dose q12h. CrCl ≤10mL/min or SrCr of ≥4.6mg/dL: 1/2 usual dose q18-24h. Apply reduced dosage recommendations after initial LD is given.
Pediatrics: >1 Month: Mild to Moderately Severe Infections: 25-50mg/kg/day, given tid or qid. Titrate: May increase to 100mg/kg/day for severe infections. Renal Impairment: CrCl 40-70mL/min: 60% of normal daily dose given in equally divided doses every 12 hrs. CrCl 20-40mL/min: 25% of normal daily dose given in equally divided doses every 12 hrs. CrCl 5-20mL/min: 10% of normal daily dose every 24 hrs. Apply reduced dosage recommendations after initial LD is given.
Inj: 500mg, 1g, 10g, 20g
Caution with penicillin (PCN) allergy; possible cross-hypersensitivity among β-lactam antibiotics. D/C if an allergic reaction develops. Clostridium difficile-associated diarrhea (CDAD) reported. May result in bacterial resistance with prolonged use or use in the absence of a proven/suspected bacterial infection or a prophylactic indication; take appropriate measures if superinfection develops. Seizures may occur if inappropriately high doses are administered to patients with renal impairment. Caution with history of colitis or other GI diseases. Safety in premature infants and neonates not established. Lab test interactions may occur. May cause a fall in prothrombin activity; caution in patients with renal/hepatic impairment or poor nutritional state, patients on protracted course of antimicrobial therapy, and in patients previously stabilized on anticoagulant therapy; monitor PT and administer vitamin K as indicated.
Diarrhea, oral candidiasis, N/V, stomach cramps, anorexia, allergic reactions, blood dyscrasias, renal failure, transient rise in AST/ALT/BUN/SrCr/alkaline phosphatase, genital and anal pruritus.
Decreased renal tubular secretion with probenecid.
Category B, caution in nursing.
Cephalosporin (1st generation); inhibits cell wall synthesis.
Absorption: Cmax=185mcg/mL. Distribution: Crosses placenta; found in breast milk. Elimination: Urine (unchanged); T1/2=1.8 hrs.
Assess for hypersensitivity to PCN, renal/hepatic impairment, history of GI disease (eg, colitis), nutritional status, pregnancy/nursing status, and possible drug interactions.
Monitor for signs/symptoms of a hypersensitivity reaction, CDAD, drug resistance or superinfection. Monitor PT in patients at risk of a fall in prothrombin activity. Monitor for seizures in patients with renal dysfunction.
Inform drug only treats bacterial, not viral, infections. Instruct to take as directed; skipping doses or not completing full course may decrease effectiveness and increase resistance. Advise to d/c therapy and notify physician if an allergic reaction or diarrhea occurs. Instruct to notify if pregnant/nursing.
Administration: IV route. Storage: -20°C (-4°F). Do not force thaw by immersion in water baths or by microwave irridiation. Thawed solution is stable for 30 days under refrigeration 5°C (41°F) and for 48 hrs at 25°C (77°F). Do not refreeze thawed antibiotics.